diff --git a/Marlin/src/HAL/STM32/pinsDebug.h b/Marlin/src/HAL/STM32/pinsDebug.h
index 21cd2de39f..b14c9c721c 100644
--- a/Marlin/src/HAL/STM32/pinsDebug.h
+++ b/Marlin/src/HAL/STM32/pinsDebug.h
@@ -150,7 +150,7 @@ const XrefInfo pin_xref[] PROGMEM = {
 
 #ifndef M43_NEVER_TOUCH
   #define _M43_NEVER_TOUCH(x) WITHIN(x, 9, 12) // SERIAL/USB pins: PA9(TX) PA10(RX) PA11(USB_DM) PA12(USB_DP)
-  #ifdef KILL_PIN
+  #if PIN_EXISTS(KILL)
     #define M43_NEVER_TOUCH(x) m43_never_touch(x)
 
     bool m43_never_touch(const pin_t index) {
diff --git a/Marlin/src/HAL/STM32F1/SPI.h b/Marlin/src/HAL/STM32F1/SPI.h
index 27bf684388..72063df699 100644
--- a/Marlin/src/HAL/STM32F1/SPI.h
+++ b/Marlin/src/HAL/STM32F1/SPI.h
@@ -33,12 +33,14 @@
 #include <stdint.h>
 #include <wirish.h>
 
+#include "../../core/macros.h"  // for PIN_EXISTS
+
 // Number of SPI ports
-#ifdef BOARD_SPI3_SCK_PIN
+#if PIN_EXISTS(BOARD_SPI3_SCK)
   #define BOARD_NR_SPI 3
-#elif defined(BOARD_SPI2_SCK_PIN)
+#elif PIN_EXISTS(BOARD_SPI2_SCK)
   #define BOARD_NR_SPI 2
-#elif defined(BOARD_SPI1_SCK_PIN)
+#elif PIN_EXISTS(BOARD_SPI1_SCK)
   #define BOARD_NR_SPI 1
 #endif
 
diff --git a/Marlin/src/feature/controllerfan.cpp b/Marlin/src/feature/controllerfan.cpp
index 585568b250..07c6d0ad62 100644
--- a/Marlin/src/feature/controllerfan.cpp
+++ b/Marlin/src/feature/controllerfan.cpp
@@ -44,9 +44,30 @@ uint8_t ControllerFan::speed;
 
 void ControllerFan::setup() {
   SET_OUTPUT(CONTROLLER_FAN_PIN);
-  #ifdef CONTROLLER_FAN2_PIN
+  #if PIN_EXISTS(CONTROLLER_FAN2)
     SET_OUTPUT(CONTROLLER_FAN2_PIN);
   #endif
+  #if PIN_EXISTS(CONTROLLER_FAN3)
+    SET_OUTPUT(CONTROLLER_FAN3_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN4)
+    SET_OUTPUT(CONTROLLER_FAN4_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN5)
+    SET_OUTPUT(CONTROLLER_FAN5_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN6)
+    SET_OUTPUT(CONTROLLER_FAN6_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN7)
+    SET_OUTPUT(CONTROLLER_FAN7_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN8)
+    SET_OUTPUT(CONTROLLER_FAN8_PIN);
+  #endif
+  #if PIN_EXISTS(CONTROLLER_FAN9)
+    SET_OUTPUT(CONTROLLER_FAN9_PIN);
+  #endif
   init();
 }
 
@@ -73,10 +94,10 @@ void ControllerFan::update() {
       #if ALL(HAS_HEATED_BED, CONTROLLER_FAN_BED_HEATING)
         || thermalManager.temp_bed.soft_pwm_amount > 0
       #endif
-      #ifdef CONTROLLER_FAN_MIN_BOARD_TEMP
+      #if PIN_EXISTS(CONTROLLER_FAN_MIN_BOARD_)
         || thermalManager.wholeDegBoard() >= CONTROLLER_FAN_MIN_BOARD_TEMP
       #endif
-      #ifdef CONTROLLER_FAN_MIN_SOC_TEMP
+      #if PIN_EXISTS(CONTROLLER_FAN_MIN_SOC_)
         || thermalManager.wholeDegSoc() >= CONTROLLER_FAN_MIN_SOC_TEMP
       #endif
     ) lastComponentOn = ms; //... set time to NOW so the fan will turn on
@@ -107,19 +128,38 @@ void ControllerFan::update() {
         fan_kick_end = 0;
     #endif
 
+    #define SET_CONTROLLER_FAN(N) do { \
+      if (PWM_PIN(CONTROLLER_FAN##N##_PIN)) hal.set_pwm_duty(pin_t(CONTROLLER_FAN##N##_PIN), speed); \
+      else WRITE(CONTROLLER_FAN##N##_PIN, speed > 0);\
+    } while (0)
+
     #if ENABLED(FAN_SOFT_PWM)
       soft_pwm_speed = speed;
     #else
-      if (PWM_PIN(CONTROLLER_FAN_PIN))
-        hal.set_pwm_duty(pin_t(CONTROLLER_FAN_PIN), speed);
-      else
-        WRITE(CONTROLLER_FAN_PIN, speed > 0);
-
-      #ifdef CONTROLLER_FAN2_PIN
-        if (PWM_PIN(CONTROLLER_FAN2_PIN))
-          hal.set_pwm_duty(pin_t(CONTROLLER_FAN2_PIN), speed);
-        else
-          WRITE(CONTROLLER_FAN2_PIN, speed > 0);
+      SET_CONTROLLER_FAN();
+      #if PIN_EXISTS(CONTROLLER_FAN2)
+        SET_CONTROLLER_FAN(2);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN3)
+        SET_CONTROLLER_FAN(3);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN4)
+        SET_CONTROLLER_FAN(4);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN5)
+        SET_CONTROLLER_FAN(5);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN6)
+        SET_CONTROLLER_FAN(6);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN7)
+        SET_CONTROLLER_FAN(7);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN8)
+        SET_CONTROLLER_FAN(8);
+      #endif
+      #if PIN_EXISTS(CONTROLLER_FAN9)
+        SET_CONTROLLER_FAN(9);
       #endif
     #endif
   }
diff --git a/Marlin/src/pins/pins_postprocess.h b/Marlin/src/pins/pins_postprocess.h
index 2c29cf4d8c..0934d25c1a 100644
--- a/Marlin/src/pins/pins_postprocess.h
+++ b/Marlin/src/pins/pins_postprocess.h
@@ -629,7 +629,7 @@
 //
 
 #if HAS_X_AXIS
-  #ifdef X_STOP_PIN
+  #if PIN_EXISTS(X_STOP)
     #if X_HOME_TO_MIN
       #define X_MIN_PIN X_STOP_PIN
     #elif X_HOME_TO_MAX
@@ -657,7 +657,7 @@
 #endif
 
 #if HAS_Y_AXIS
-  #ifdef Y_STOP_PIN
+  #if PIN_EXISTS(Y_STOP)
     #if Y_HOME_TO_MIN
       #define Y_MIN_PIN Y_STOP_PIN
     #elif Y_HOME_TO_MAX
@@ -685,7 +685,7 @@
 #endif
 
 #if HAS_Z_AXIS
-  #ifdef Z_STOP_PIN
+  #if PIN_EXISTS(Z_STOP)
     #if Z_HOME_TO_MIN
       #define Z_MIN_PIN Z_STOP_PIN
     #elif Z_HOME_TO_MAX
@@ -716,7 +716,7 @@
 #endif
 
 #if HAS_I_AXIS
-  #ifdef I_STOP_PIN
+  #if PIN_EXISTS(I_STOP)
     #if I_HOME_TO_MIN
       #define I_MIN_PIN I_STOP_PIN
     #elif I_HOME_TO_MAX
@@ -730,7 +730,7 @@
 #endif
 
 #if HAS_J_AXIS
-  #ifdef J_STOP_PIN
+  #if PIN_EXISTS(J_STOP)
     #if J_HOME_TO_MIN
       #define J_MIN_PIN J_STOP_PIN
     #elif J_HOME_TO_MAX
@@ -744,7 +744,7 @@
 #endif
 
 #if HAS_K_AXIS
-  #ifdef K_STOP_PIN
+  #if PIN_EXISTS(K_STOP)
     #if K_HOME_TO_MIN
       #define K_MIN_PIN K_STOP_PIN
     #elif K_HOME_TO_MAX
@@ -758,7 +758,7 @@
 #endif
 
 #if HAS_U_AXIS
-  #ifdef U_STOP_PIN
+  #if PIN_EXISTS(U_STOP)
     #if U_HOME_TO_MIN
       #define U_MIN_PIN U_STOP_PIN
     #elif U_HOME_TO_MAX
@@ -772,7 +772,7 @@
 #endif
 
 #if HAS_V_AXIS
-  #ifdef V_STOP_PIN
+  #if PIN_EXISTS(V_STOP)
     #if V_HOME_TO_MIN
       #define V_MIN_PIN V_STOP_PIN
     #elif V_HOME_TO_MAX
@@ -786,7 +786,7 @@
 #endif
 
 #if HAS_W_AXIS
-  #ifdef W_STOP_PIN
+  #if PIN_EXISTS(W_STOP)
     #if W_HOME_TO_MIN
       #define W_MIN_PIN W_STOP_PIN
     #elif W_HOME_TO_MAX
@@ -1871,9 +1871,9 @@
 
 // Get a NeoPixel pin from the LCD or board, if provided
 #ifndef NEOPIXEL_PIN
-  #ifdef LCD_NEOPIXEL_PIN
+  #if PIN_EXISTS(LCD_NEOPIXEL)
     #define NEOPIXEL_PIN LCD_NEOPIXEL_PIN
-  #elif defined(BOARD_NEOPIXEL_PIN)
+  #elif PIN_EXISTS(BOARD_NEOPIXEL)
     #define NEOPIXEL_PIN BOARD_NEOPIXEL_PIN
   #endif
 #endif
diff --git a/Marlin/src/sd/usb_flashdrive/lib-uhs3/UHS_host/USB_HOST_SHIELD/USB_HOST_SHIELD_INLINE.h b/Marlin/src/sd/usb_flashdrive/lib-uhs3/UHS_host/USB_HOST_SHIELD/USB_HOST_SHIELD_INLINE.h
index f126a6fcef..1dde32f949 100644
--- a/Marlin/src/sd/usb_flashdrive/lib-uhs3/UHS_host/USB_HOST_SHIELD/USB_HOST_SHIELD_INLINE.h
+++ b/Marlin/src/sd/usb_flashdrive/lib-uhs3/UHS_host/USB_HOST_SHIELD/USB_HOST_SHIELD_INLINE.h
@@ -303,7 +303,7 @@ int16_t UHS_NI MAX3421E_HOST::Init(int16_t mseconds) {
   pinMode(ss_pin, OUTPUT);
   MARLIN_UHS_WRITE_SS(HIGH);
 
-  #ifdef USB_HOST_SHIELD_TIMING_PIN
+  #if PIN_EXISTS(USB_HOST_SHIELD_TIMING)
     pinMode(USB_HOST_SHIELD_TIMING_PIN, OUTPUT);
     // My counter/timer can't work on an inverted gate signal
     // so we gate using a high pulse -- AJK
@@ -863,7 +863,7 @@ void UHS_NI MAX3421E_HOST::ISRbottom() {
       interrupts();
     }
   #endif
-  #ifdef USB_HOST_SHIELD_TIMING_PIN
+  #if PIN_EXISTS(USB_HOST_SHIELD_TIMING)
     // My counter/timer can't work on an inverted gate signal
     // so we gate using a high pulse -- AJK
     UHS_PIN_WRITE(USB_HOST_SHIELD_TIMING_PIN, LOW);
@@ -969,7 +969,7 @@ void UHS_NI MAX3421E_HOST::ISRbottom() {
     if (!sof_countdown && !counted && !usb_task_polling_disabled) {
       DisablePoll();
       //usb_task_polling_disabled++;
-      #ifdef USB_HOST_SHIELD_TIMING_PIN
+      #if PIN_EXISTS(USB_HOST_SHIELD_TIMING)
         // My counter/timer can't work on an inverted gate signal
         // so we gate using a high pulse -- AJK
         UHS_PIN_WRITE(USB_HOST_SHIELD_TIMING_PIN, HIGH);