diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 1428453347..aea4ad4473 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -55,6 +55,7 @@
 //#define MachineEnder2Pro
 //#define MachineEnder3V2
 //#define MachineEnder3S1
+//#define MachineEnder3S1_F4
 //#define MachineEnder3Max
 //#define MachineEnder3Pro422
 //#define MachineEnder3Pro427
@@ -85,7 +86,7 @@
 // Enable this if you used a plug and play creality e3d or mosquito kit and kept the Creality thermistor
 //#define CrealityThermistor
 
-//#define SlicePT1000 // Enable this if you have a mosquito with the newer PT1000 sensor
+#define SlicePT1000 // Enable this if you have a mosquito with the newer PT1000 sensor
 //#define PID50W //Set PID for 50W Heater
 /*
  * Select these if you have changed to a high performance extruder
@@ -441,6 +442,11 @@
   #endif
 #endif
 
+#if ENABLED(MachineEnder3S1_F4)
+  #define MachineEnder3S1
+#endif
+
+
 #if ENABLED(MachineEnder3S1)
   #if NONE(ABL_NCSW, ABL_EZABL, ABL_BLTOUCH)
     #define ABL_BLTOUCH
@@ -763,7 +769,9 @@
     #define MOTHERBOARD BOARD_CREALITY_V427
   #elif ENABLED(Creality422)
     #define MOTHERBOARD BOARD_CREALITY_V4
-  #elif ENABLED(MachineEnder3S1)
+  #elif ENABLED(MachineEnder3S1_F4)
+    #define MOTHERBOARD BOARD_CREALITY_V24S1_301F4
+  #elif ENABLED(MachineEnder3S1) && DISABLED(MachineEnder3S1_F4)
     #define MOTHERBOARD BOARD_CREALITY_V24S1_301
   #elif (ENABLED(MachineCR10Orig) && DISABLED(Melzi_To_SBoardUpgrade))
     #define MOTHERBOARD BOARD_MELZI_CREALITY
@@ -3112,7 +3120,7 @@
  * NOTE: Requires a lot of PROGMEM!
  */
 #if ENABLED(MachineLargeROM)
-  #define DEBUG_LEVELING_FEATURE
+  //#define DEBUG_LEVELING_FEATURE
 #endif
 
 #if ANY(MESH_BED_LEVELING, AUTO_BED_LEVELING_UBL, PROBE_MANUALLY)
diff --git a/Marlin/src/pins/stm32f1/pins_CREALITY_V4.h b/Marlin/src/pins/stm32f1/pins_CREALITY_V4.h
index d8ef00d882..535f049351 100644
--- a/Marlin/src/pins/stm32f1/pins_CREALITY_V4.h
+++ b/Marlin/src/pins/stm32f1/pins_CREALITY_V4.h
@@ -129,11 +129,6 @@
 #endif
 #define E0_ENABLE_PIN               X_ENABLE_PIN
 
-//
-// Release PB4 (Y_ENABLE_PIN) from JTAG NRST role
-//
-#define DISABLE_DEBUG
-
 //
 // Temperature Sensors
 //
diff --git a/platformio.ini b/platformio.ini
index 4b037f40a3..30e71ec9e5 100644
--- a/platformio.ini
+++ b/platformio.ini
@@ -349,6 +349,8 @@ default_envs =
   Ender3_427_LR
   Ender3_427_BLT_LR
   Ender3_427_BLT_ZM_LR
+  Ender3S1
+  Ender3S1F4
   Ender3Max_422
   Ender3Max_422_BLT
   Ender3Max_422_BLT_ZM
@@ -3939,6 +3941,23 @@ build_flags                 = ${stm32_variant.build_flags}
                               -DSS_TIMER=4 -DTIMER_SERVO=TIM5
                               -DENABLE_HWSERIAL3 -DTRANSFER_CLOCK_DIV=8      -DMachineEnder3S1
 
+# Ender-3 S1 STM32F401RC_creality
+#
+[env:Ender3S1F4]
+extends                     = stm32_variant
+board                       = genericSTM32F401RC
+board_build.variant         = MARLIN_CREALITY_STM32F401RC
+board_build.offset          = 0x10000
+board_upload.offset_address = 0x08010000
+build_flags                 = ${stm32_variant.build_flags} -DMCU_STM32F401RC -DSTM32F4
+                              -DSS_TIMER=4 -DTIMER_SERVO=TIM5
+                              -DENABLE_HWSERIAL3 -DTRANSFER_CLOCK_DIV=8
+                              -DMachineEnder3S1_F4
+build_unflags               = ${stm32_variant.build_unflags} -DUSBCON -DUSBD_USE_CDC
+extra_scripts               = ${stm32_variant.extra_scripts}
+                              pre:buildroot/share/PlatformIO/scripts/random-bin.py
+monitor_speed               = 115200
+
 [env:Ender2Pro]
 extends                     = stm32_variant
 board_build.variant         = MARLIN_F103Rx