diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index efbbb41f80..41dfc36e8b 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -1765,12 +1765,12 @@
    */
   #define  X_SLAVE_ADDRESS 0
   #define  Y_SLAVE_ADDRESS 0
-  #define  Z_SLAVE_ADDRESS 0
+  #define  Z_SLAVE_ADDRESS 1
   #define X2_SLAVE_ADDRESS 0
   #define Y2_SLAVE_ADDRESS 0
   #define Z2_SLAVE_ADDRESS 3
   #define Z3_SLAVE_ADDRESS 0
-  #define E0_SLAVE_ADDRESS 0
+  #define E0_SLAVE_ADDRESS 2
   #define E1_SLAVE_ADDRESS 0
   #define E2_SLAVE_ADDRESS 0
   #define E3_SLAVE_ADDRESS 0
diff --git a/Marlin/src/pins/ramps/pins_RAMPS.h b/Marlin/src/pins/ramps/pins_RAMPS.h
index 518ac50516..1b4930f5c5 100644
--- a/Marlin/src/pins/ramps/pins_RAMPS.h
+++ b/Marlin/src/pins/ramps/pins_RAMPS.h
@@ -331,13 +331,13 @@
   #define Y2_SERIAL_TX_PIN   -1
   #define Y2_SERIAL_RX_PIN   -1
 
-  #define Z_SERIAL_TX_PIN    42
-  #define Z_SERIAL_RX_PIN    65
+  #define Z_SERIAL_TX_PIN    59
+  #define Z_SERIAL_RX_PIN    64
   #define Z2_SERIAL_TX_PIN   59
   #define Z2_SERIAL_RX_PIN   64
 
-  #define E0_SERIAL_TX_PIN   44
-  #define E0_SERIAL_RX_PIN   66
+  #define E0_SERIAL_TX_PIN   59
+  #define E0_SERIAL_RX_PIN   64
   #define E1_SERIAL_TX_PIN   -1
   #define E1_SERIAL_RX_PIN   -1
   #define E2_SERIAL_TX_PIN   -1