diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 209b4a4e14..1ce64489f3 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -631,7 +631,11 @@
  * Multiple extruders can be assigned to the same pin in which case
  * the fan will turn on when any selected extruder is above the threshold.
  */
-#define E0_AUTO_FAN_PIN -1
+#if ENABLED(MachineEnder3S1)
+  #define E0_AUTO_FAN_PIN PC0
+#else
+  #define E0_AUTO_FAN_PIN -1
+#endif
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1